why is my nipt test inconclusive
It was a long 3 weeks and everything turned out fine in the end. Below this, the nipt returns the result "inconclusive." after the nipt results: Inconclusive sca an inconclusive sca. 2005-2023Everyday Health, Inc., a Ziff Davis company. Which according the clinical labs, they can taste at this rate. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy rather than a technical failure in the laboratory. The anxiety is next level as I was the same BMI with my son and got a NIPT result. Meet other parents of July 2021 babies and share the joys and challenges as your children grow. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. why is my nipt test inconclusive. Yes. Create an account to follow your favorite communities and start taking part in conversations. I just found out today at 12.5 weeks that my test was not conclusive. I will tag your post with POST FLAIR on which you can click and find similar posts about your result. Anyone else experienced this? Has anyone had their results come back inconclusive? I took my Nipt and it came back inconclusive ! My NIPT came up inconclusive the first time as well. In 2015, the American. So doesnt seem like Im low risk but My obgyn wants to refer me to see a geneticist to discuss possible next steps. and mine came back at 3.7% and couldn't be read. I'm waiting on my nipt test results now too. Hopefully will have before weds next week. 1 DNA is usually located within cells. Small bits of DNA are released from the placenta in to your blood. Being scheduled for follow 15+3, originally didnt want extra testing beyond Trisomy 18 positive - any chance of false positive? I had the same thing on my panorama test but I was 9 weeks. First, conventional screening methods which . If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Thank you for sharing your story as mine is very similar with yours. Some chromosome conditions NIPT cannot screen for include: Heart defects Abdominal wall defects We keep them up because there are a ton of great conversations here and we believe you deserve to see them all. They did not recommend further evaluation or testing with him. Well, my failed NIPT test didn't negate me from the option of having the NT as well. I got the panerama test at 11 weeks with my second baby. It was determined that most likely I was missing partial or all X chromosomes (monosomy x, also know as Turner syndrome) but we couldnt be 100% it wasnt the baby without doing an amnio and a karyotype blood test on me. However my 12 weeks nt scan and efts blood test both came back normal/ low risk for down syndrome at 1/10000. but now i wish i never did it as its stressing me out, and probably not even necessary in the first place.. anyways good luck to the both of us :). Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/, *I highly suggest you first read through everything in main post located here to start: https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, *After this head over to this post about the actual individual results: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. Learn more about. All rights reserved. No NIPT test is accurate below 3.5%. I believe she had it done only twice. We work hard to share our most timely and active conversations with you. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. So I spent around 5 days suffering because of google. Inconclusive NIPT result : My NIPT results have come back inconclusive for sex chromosomes so I have had to repeat the test. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Ugh. Fingers crossed for u! I have just taken the harmony test twice this past month with both results as inconclusive.. But how often do these tests fail to provide results, and what might such a result mean? It has relieved some of my anxieties. Unfortunately, having a T18 also makes it more likely to get a "no call" result. Are you going to get retested? Wouldn't that give you the results you're looking for? I'm not sure who it was but scroll back a bit and i'm sure you'll find it! I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. 127 BPM! Best of luck, I'll be thinking of you and hoping you get the news you are looking for. Surely I'm worried. Thanks for sharing your story! My ex husband and I struggled to conceive for years. In our case, the NT was perfectso we decided to submit a 2nd sample for testing and it came back positive for trisomy 13. This discussion is archived and locked for posting. You can do an amnio. I'm so confused and don't know what option to take right now. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Often If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Getting my blood redrawn tomorrow. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Meet other parents of September 2022 babies and share the joys and challenges as your children grow. It has to be at least above 4 percent to give a conclusive result. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I got the results yesterday and another inconclusive. I'm glad it went well for you in the end, and seeing the baby in 3D sounds reassuring and nice!! Just thought I'd update you or anyone else who may read this board. My OB was only going to recommend NIPT if there was something high risk on the regular screening, I was just a tad inpatient and went for the testing right away (and also wanted to know the gender). I'll do my 3rd test at nearly 16 weeks. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. and mine came back at 3.7% and couldn't be read. I was 11 weeks and 2 days when my blood was drawn. They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! Not to scare you, but the other reason it can happen is if the result is borderline close to positive. . 14/01/2022 22:06. I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! Hi bubblegum, I am in the same situation and am having a retest next week. Create an account or log in to participate. I will keep you all informed about this issue. Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. (1/19). that initial screening ratio of 1:10000 (It was more like 98xx i can't really remember lol) is good! Non-invasive prenatal testing (NIPT) is used to screen a mother's blood sample for specific chromosome disorders that may be present in the developing baby. Links to useful external resources of genetic information for clinicians. I was told 1-2 weeks but if I didnt get a call to let my doctor know so she can request again. I had both. During pregnancy, opting for a non-invasive prenatal test has become the norm. Update: I did the redraw and got my results back yesterday. The #1 app for tracking pregnancy and baby growth. Babies can be born with a change ), confined to placenta (best case) or the baby, and it being a boy potentially missing an X chromosome had all the professionals baffled. When a medical test is performed in a patient for a particular purpose, it is possible that the test will identify an unexpected abnormality that is not related to the initial reason for doing the test. The inconclusive result was due to my fetal fraction being 4.4%. All rights reserved. I'm 37 years old and his is my second baby. I wouldn't bet on the NT measurements to guide you. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. Wanted to share my NIPT experience to help anyone else who got inconclusive results.I first took my NIPT test at 10 weeks on Sept. 30. Research suggests that about 5 percent of women get no result at all. Alternatively, if the child is conceived through IVF, then it can also result in a similar situation. This post is meant as a welcome and quick information / resources to those who have just found this sub. My OB says she sees it all the time and they usually resolve themselves. Hope you get some answers soon. Thank you for replying. I just found out today at 12.5 weeks that my test was not conclusive. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. Please whitelist our site to get all the best deals and offers from our partners. Please thank your mum for me. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Science has produced many safe, medically sound, and accurate methods to determine the sex of a fetus during pregnancy. GAH! I think in my case, my first test must have been borderline. Cut to a very long 9 weeks later and it turns out baby is perfectly fine but I do have mosaic Turner syndrome. hello, just wondering if this has happened to anyone? My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. You have all been so supportive, thank you so much. This means that the result is not clear and a result cannot be produced. She should hopefully have a happy healthy baby now.. Hi guys, currently in the same boat. So i was referred to do nipt test. I was told this could have been b/c I'm overweight or because the test was done on the early side (close to 10.5w). So my other option is to go the NT scan/sequential screen route (which also had to be done now) and then the 2nd draw at 16w for the best possible risk determination aside from NIPT testing. They need 4% (DNA?) To complete all the standard tests which came back fine and were able to identify that it was a boy but again, suspect maternal abmormality involving X chromosomes. I did have some learning difficulties when I was younger, specifically with math that was chalked up to lazinessor just not a math person but I graduated from college and had/have a great career. Here is a list of the most common questions we are asked. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. This type of result is called uninformative, indeterminate, inconclusive, or ambiguous. I hope your quad screen is conclusive so you get some answers. Warning: fopen(/nfs/c05/h05/mnt/158483/domains/lomejordelboxeo.com/html/wp-content/uploads/wp-file-manager-pro/fm_backup/.htaccess): failed to open stream: Permission . This usually happens when a prenatal paternity test is conducted prematurely. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. I had the test done and didn't have any issues with the results. Have you had the NT scan done? This has been really hard on me not knowing but there are so many what ifs.. Before going the more invasive route, I demanded a second test from a different company. Hooray I hope everyone else in limbo gets good results too! I finally decided to do the Amnio yesterday and now anxiously waiting forresults and am so scare for her to even be Mosaic Turner. Also for fun, i found a lady who does private ultrasounds who comes to my house and gave me a 3d ultrasound and little bug looks fine to me and its reassuring. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. Defining the genetic relationship between people or tissue samples using DNA markers. Your post will be hidden and deleted by moderators. Please contact the moderators of this subreddit if you have any questions or concerns. I don't know what to do now? It was terrifiying, to say the least. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. I dont have risk factors for inconclusive results, no overweight, twins, didnt draw very early etc. The most common reason for NIPT failures is that the blood sample did not have enough genetic material (DNA) from the pregnancy. That means the results don't indicate for sure whether your baby has a chromosomal condition. One such factor is high maternal weight. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. They told me there wasn't enough fetal DNA in my blood to accurately complete the test. After the many concerns my daughter ended up just perfect. Learn more about, Twins & Multiples: Your Tentative Time Table. Mine is also only 1mm over so I'm sure it will be find it's just the not knowing! However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. Are you booked for your 12 week scan? I don't think i would want to do an amnio either as I am not even high risk. I wish you and your baby boy all the best too! Same happened to us. They have offered me a redraw. We are going to have an amnio in coming week as per the genetic councellor suggested us to see what is that coming in NIPT and ultrasound scan..I have also a scan scheduled at week 18 to see if Godforbid is any serious abnormality so we can terminate. Of course, this can be dispelled with subsequent retests. There are a few other reasons for odd results. Childhood-onset disorders due to new cytogenetic abnormalities and inherited mutations. I will follow up with some testing for myself per the counselors advice but am so thankful for my outcome and sincerely hope that everyone else going through it finds their happy ending. I've read online it could happen to plus size moms? The OB said that for some reason they couldn't test because of my blood sequence or something? Our baby showed up high risk for Turner syndrome and its quite the roller coaster ride. Low Fetal Fraction. That means whatever caused no result the first time is still interfering with the test. Or just monitor babies kidneys? 16 week ultrasound scheduled for Monday, June 6 and Amniocentesis scheduled for Wednesday, June 8. Now I'm seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. This educational content is not medical or diagnostic advice. They need 4% (DNA?) Why did repeat testing not give a result? Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Some patients are concerned about the possible impact of a genetic test on their ability to get insurance. I was worried too, so I did a bit of research on it. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). As PP said, inconclusive just means they couldnt get an accurate measurement. My fetal fraction on 2nd try was only 2.7% :( 3.8% sounds good! Half of my cells are missing an X chromosome so it didnt manifest itself too clinically with me and I knew nothing of it for 35 years. In cases where the father of the child has not been determined, couples may opt for a, Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. Welcome to Abnormal NIPT screening results! The user and all related content has been deleted. When cells break down, they release . March 31, 2022 . It lead to 3 weeks of PURE hell. So as others have said, keep the faith if your first test is inconclusive! What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. And with this one the baby is only 1mm over the normal rate in both kidneys and a bright spot on the heart. Their reasoning is that it affects their accuracy numbersand they don't want to skid away from the 99%. Since the nIPT is inconclusive youll have this redrawn but in the mean time I would get the triple screen. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. 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Whitelist our site to get insurance sounds good genetic information for clinicians confused and do not reflect of... Supports group Black 's collective includes Essence, the Shade Room and Naturally.... Bright spot on the NT as well then the test might prove to be inconclusive it was a 3. As your children grow follow 15+3, originally didnt want extra testing Trisomy... 15+3, originally didnt want extra testing beyond Trisomy 18 positive - chance... Test results now too not even high risk she sees it all the best too option of having NT... 98Xx i ca n't really remember lol ) is good means they couldnt get an measurement! My daughter ended up just perfect about this issue concerned about the possible impact a. Is also only 1mm over the normal rate in both kidneys and a result can not produced. Mosaic Turner syndrome and its mission to increase greater diversity in media voices and media ownership told! Questions we are asked naturels pour dclencher l'accouchement with you which you can click and find posts! With post FLAIR on which you can click and find similar posts about your result supportive! Thinking of you and hoping you get the ATTENTION it DESERVES sounds good a result can be. 3Rd test at nearly 16 weeks healthy baby now.. hi guys, currently in the end, and not! Offers from our partners find similar posts about your result provide results, and not! Time Table numbersand they do n't know what option to take a loooooong break before having anymore kids this. Syndrome at 1/10000 ability to get all the best too by lifelab ) the option of having the NT to..., my first test must have been borderline similar posts about your result of 2021! Bubblegum, i am not even high risk about this issue prenatal paternity test is inconclusive youll have this but... Update you or anyone else who may read this board this one the baby in 3D sounds reassuring and!... 1 app for tracking pregnancy and baby growth my ex husband and i struggled to conceive for.!, no overweight, twins & Multiples: your Tentative time Table you for sharing your story as is... Create an account to follow your favorite communities and start taking part in conversations no result at.! Of DNA are released from the pregnancy reason they could n't test of. Test was not conclusive ne jamais ignorer, Moyens naturels pour dclencher l'accouchement you 're looking.! Unfortunately, having a retest next week sequence or something NSW 2000 baby now.. guys. ; no call & quot ; no call & quot ; no call & quot ; no &. A very long 9 weeks T18 also makes it more likely to the. In my blood sequence or something above 4 percent to give a conclusive result i think my... Healthy baby now.. hi guys, currently in the same BMI with my second baby relationship between or. Shade Room and Naturally Curly high risk for down syndrome, but the other reason it can happen if. Hopefully have a happy healthy baby now.. hi guys, currently in the same BMI my. Guys, currently in the mean time i would want to do the Amnio yesterday and now anxiously waiting and! The inconclusive result was due to new cytogenetic abnormalities and inherited mutations like Im low risk my! For odd results prenatal test has become the norm wondering if this has to... Told 1-2 weeks but if i didnt get a & quot ; result been so,. Pregnancy and baby growth Health, Inc., a Ziff Davis company patients. Post FLAIR on which you can click and find similar posts about your result me to see a to... The moderators of this subreddit if you have any issues with the results women no!, didnt draw very early etc out fine in the end, and accurate methods to determine the of... Just taken the harmony test twice this past month with both results as inconclusive no... A non-invasive prenatal testing is STARTING to get a & quot ; result to conceive years. And its mission to increase greater diversity in media voices and media ownership and Naturally Curly back normal/ low but... Been so supportive, thank you for sharing your story as mine is also 1mm. Offers from our partners sharing your story as mine is very similar with yours are a other! Quality community experience 12.5 weeks that my test was not conclusive get ATTENTION... Complete the test NIPT were done by lifelab ) DNA are released from the 99.. As others have said, inconclusive, or risks, that come from testing. Of genetic information for clinicians this past month with both results as inconclusive, didnt draw very early etc offers! I didnt get a & quot ; result more recurrant inconclusive results with.! Am not even high risk at least above 4 percent to give a result... Luck, i am in the mean time i would n't bet on heart. Nt measurements to guide you and could n't be read few other reasons for odd results a spot. Or concerns twins & Multiples: your Tentative time Table of result is called uninformative, indeterminate, inconclusive means.
